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Journal of Clinical Microbiology, May 2005, p. 2492-2493, Vol. 43, No. 5
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.5.2492-2493.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clonal Spread of Pediatric Isolates of Ciprofloxacin-Resistant, emm Type 6 Streptococcus pyogenes

Rodrigo Alonso,1* Estibaliz Mateo,1 Marc Galimand,2 Javier Garaizar,1 P. Courvalin,2 and Ramón Cisterna1,3

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Farmacia, Universidad del País Vasco, 01006 Vitoria-Gasteiz, Spain,1 Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France,2 Servicio de Microbiología, Hospital de Basurto, 48013 Bilbao, Spain3

Received 10 December 2004/ Returned for modification 20 January 2005/ Accepted 31 January 2005

Twenty-four community isolates of Streptococcus pyogenes resistant to ciprofloxacin and susceptible to levofloxacin, gatifloxacin, and moxifloxacin were studied. Sequence determination of the quinolone resistance-determining regions in the gyrA and parC genes revealed a T/G mutation in parC leading to a Ser79Ala substitution in ParC. All isolates were of the emm type 6, and 18 and 2 of them were indistinguishable or closely related, respectively, on the basis of pulsed-field gel electrophoresis.

* Corresponding author. Mailing address: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Farmacia, Universidad del País Vasco, Paseo de la Universidad, 7 01006-Vitoria-Gasteiz, Spain. Phone: (34) 945 01 39 08. Fax: (34) 945 01 30 14. E-mail: oipalmor{at}vc.ehu.es.

Journal of Clinical Microbiology, May 2005, p. 2492-2493, Vol. 43, No. 5
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.5.2492-2493.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Billal, D. S., Fedorko, D. P., Yan, S. S., Hotomi, M., Fujihara, K., Nelson, N., Yamanaka, N. (2007). In vitro induction and selection of fluoroquinolone-resistant mutants of Streptococcus pyogenes strains with multiple emm types. J Antimicrob Chemother 59: 28-34 [Abstract] [Full Text]  


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