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Journal of Clinical Microbiology, June 2005, p. 2575-2580, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2575-2580.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

First Reported Outbreak of Diarrhea Due to Adenovirus Infection in a Hematology Unit for Adults

Hamid Jalal,1* David F. Bibby,1 Julian W. Tang,1 Julie Bennett,1 Chara Kyriakou,2 Karl Peggs,2 David Cubitt,3 Nicola S. Brink,1 Kate N. Ward,1 and Richard S. Tedder1

Department of Infection, Centre of Virology, Royal Free and University College Medical School, Windeyer Building, 46 Cleveland Street, London W1T 4JF,1 Department of Haematology, Royal Free and University College Medical School, 98 Chenies Mews, London WC1E 6HX,2 Virology, Camelia Botnar Laboratories, Gt. Ormond Street Hospital, London WC1 N3 JH, United Kingdom3

Received 27 September 2004/ Returned for modification 13 December 2004/ Accepted 1 February 2005

Numerous outbreaks of adenovirus infection from different types of health care settings, except a hematology unit, have been reported. This is the first report describing an outbreak of adenovirus infection causing diarrhea among adult hematopoietic stem cell transplant recipients. Six of 21 patients from the outbreak cohort were affected with diarrhea. Electron microscopy, cell culture, and direct DNA sequencing of amplicons generated from stool and blood samples were used to investigate this outbreak. Electron microscopy and cell culture detected adenovirus in stools from symptomatic patients. DNA sequencing of amplicons generated from stool samples confirmed nosocomial transmission of infection from a single index case. The outbreak strain was also detected in plasma of four of these patients, suggesting systemic infection. The outbreak strain was identified as type 12. Standard infection control measures were effective to control this outbreak.

* Corresponding author. Mailing address: Clinical Microbiology & Public Health Laboratory, Addenbrooke's Hospital, Cambridge, Hills Road, Cambridge CB2 2QW, United Kingdom. Phone: 44-1223-257036. Fax: 44-1223-242775. E-mail: hamid.Jalal{at}addenbrookes.nhs.uk.

Journal of Clinical Microbiology, June 2005, p. 2575-2580, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2575-2580.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jalal, H., Bibby, D. F., Bennett, J., Sampson, R. E., Brink, N. S., MacKinnon, S., Tedder, R. S., Ward, K. N. (2007). Molecular Investigations of an Outbreak of Parainfluenza Virus Type 3 and Respiratory Syncytial Virus Infections in a Hematology Unit. J. Clin. Microbiol. 45: 1690-1696 [Abstract] [Full Text]  


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