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Journal of Clinical Microbiology, June 2005, p. 2955-2958, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2955-2958.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Gene Mutations Responsible for Overexpression of AmpC ß-Lactamase in Some Clinical Isolates of Enterobacter cloacae

Kenichi Kaneko,1 Ryoichi Okamoto,1,2 Ryuichi Nakano,1 Sayoko Kawakami,3 and Matsuhisa Inoue1,2*

Department of Environmental Infectious Diseases, Graduate School of Medical Sciences,1 Department of Microbiology, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa,2 Department of Central Laboratory, School of Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan3

Received 28 October 2004/ Returned for modification 12 December 2004/ Accepted 20 February 2005

AmpC regulatory genes in 21 ceftazidime-resistant clinical isolates of Enterobacter cloacae (MICs of ≥16 µg/ml) were characterized. All isolates exhibited AmpC overproduction due to AmpD mutation. Additionally, we found two AmpR mutants among the isolates. This is the first report of chromosomal ampR mutation in clinical isolates of E. cloacae.

* Corresponding author. Mailing address: Department of Environmental Infectious Diseases, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. Phone: 81-42-778-9349. Fax: 81-42-778-9350. E-mail: matsu{at}kitasato-u.ac.jp.

Journal of Clinical Microbiology, June 2005, p. 2955-2958, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2955-2958.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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