This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maekura, R.
Right arrow Articles by Ito, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maekura, R.
Right arrow Articles by Ito, M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, July 2005, p. 3150-3158, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3150-3158.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clinical and Prognostic Importance of Serotyping Mycobacterium avium-Mycobacterium intracellulare Complex Isolates in Human Immunodeficiency Virus-Negative Patients

Ryoji Maekura,1* Yoshinari Okuda,1 Atsusi Hirotani,1 Seigo Kitada,1 Touru Hiraga,1 Kenji Yoshimura,1 Ikuya Yano,3 Kazuo Kobayashi,2 and Masami Ito1

National Hospital Organization, Toneyama National Hospital, Toyonaka,1 Department of Host Defense, Osaka City University Graduate School of Medicine, Osaka,2 Japan BCG Laboratory, Kiyose, Japan3

Received 5 July 2004/ Returned for modification 25 August 2004/ Accepted 3 April 2005

We studied whether the serotypes of Mycobacterium avium-Mycobacterium intracellulare complex (MAC) isolates determine the prognosis for pulmonary MAC disease. We prospectively monitored a cohort of 68 patients with pulmonary MAC disease for whom the serotype-specific glycopeptidolipids in isolates were identified using thin-layer chromatography and fast atom bombardment mass-spectrometry in 1990 and 1995. Serovar 4 Mycobacterium avium was detected in 40/68 patients (58.8%). Other serotypes were serotypes 1 (five cases), 6 (three cases), 8 (seven cases), 9 (three cases), 14 (four cases), and 16 (six cases). Patients with serovar 4 were significantly (P < 0.01) younger (63.0 ± 9.8 years) than patients with other serotypes (71.8 ± 10.3). Patients who failed treatment had a significantly poorer prognosis than other patients. There were no cases of MAC-related death in the cured group. Chest radiographic findings progressively worsened in 36 (90%) of patients with serotype 4, and 14/36 died from respiratory failure caused by pulmonary Mycobacterium avium disease. The patients with serotype 4 had a significantly poorer prognosis than patients with other serotypes. These results show that both the outcome of chemotherapy and the serotypes of MAC isolates are important for assessing the prognosis of pulmonary MAC disease.

* Corresponding author. Mailing address: Toneyama National Hospital, 5-1-1, Toneyama Toyonaka-City, Osaka 560-0045, Japan. Phone: 81-6-6853-2001. Fax:81-6-6853-3127. E-mail: maekurar{at}toneyama.hosp.go.jp.

Journal of Clinical Microbiology, July 2005, p. 3150-3158, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3150-3158.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kikuchi, T, Watanabe, A, Gomi, K, Sakakibara, T, Nishimori, K, Daito, H, Fujimura, S, Tazawa, R, Inoue, A, Ebina, M, Tokue, Y, Kaku, M, Nukiwa, T (2009). Association between mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection. Thorax 64: 901-907 [Abstract] [Full Text]  
  • Inagaki, T., Nishimori, K., Yagi, T., Ichikawa, K., Moriyama, M., Nakagawa, T., Shibayama, T., Uchiya, K.-i., Nikai, T., Ogawa, K. (2009). Comparison of a Variable-Number Tandem-Repeat (VNTR) Method for Typing Mycobacterium avium with Mycobacterial Interspersed Repetitive-Unit-VNTR and IS1245 Restriction Fragment Length Polymorphism Typing. J. Clin. Microbiol. 47: 2156-2164 [Abstract] [Full Text]  
  • Schorey, J. S, Sweet, L. (2008). The mycobacterial glycopeptidolipids: structure, function, and their role in pathogenesis. Glycobiology 18: 832-841 [Abstract] [Full Text]  
  • Fujiwara, N., Nakata, N., Naka, T., Yano, I., Doe, M., Chatterjee, D., McNeil, M., Brennan, P. J., Kobayashi, K., Makino, M., Matsumoto, S., Ogura, H., Maeda, S. (2008). Structural Analysis and Biosynthesis Gene Cluster of an Antigenic Glycopeptidolipid from Mycobacterium intracellulare. J. Bacteriol. 190: 3613-3621 [Abstract] [Full Text]  
  • Kitada, S., Nishiuchi, Y., Hiraga, T., Naka, N., Hashimoto, H., Yoshimura, K., Miki, K., Miki, M., Motone, M., Fujikawa, T., Kobayashi, K., Yano, I., Maekura, R. (2007). Serological test and chest computed tomography findings in patients with Mycobacterium avium complex lung disease. Eur Respir J 29: 1217-1223 [Abstract] [Full Text]  
  • Fujiwara, N., Nakata, N., Maeda, S., Naka, T., Doe, M., Yano, I., Kobayashi, K. (2007). Structural Characterization of a Specific Glycopeptidolipid Containing a Novel N-Acyl-Deoxy Sugar from Mycobacterium intracellulare Serotype 7 and Genetic Analysis of Its Glycosylation Pathway. J. Bacteriol. 189: 1099-1108 [Abstract] [Full Text]  
  • Fujita, Y., Doi, T., Maekura, R., Ito, M., Yano, I. (2006). Differences in serological responses to specific glycopeptidolipid-core and common lipid antigens in patients with pulmonary disease due to Mycobacterium tuberculosis and Mycobacterium avium complex. J Med Microbiol 55: 189-199 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»