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Journal of Clinical Microbiology, July 2005, p. 3237-3243, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3237-3243.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Ceftriaxone Resistance of Nontyphoidal Salmonella enterica Isolates in Northern Taiwan Attributable to Production of CTX-M-14 and CMY-2 ß-Lactamases

Wen-Chen Li,1 Fu-Yuan Huang,1,2 Chang-Pan Liu,3,4,5 Li-Chuan Weng,3 Nai-Yu Wang,3 Nan-Chang Chiu,1,5 and Chuen-Sheue Chiang3,6*

Department of Pediatrics,1 Microbiology Section, Department of Medical Research,3 Division of Infectious Diseases, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan,4 Taipei Medical University, Taipei, Taiwan,2 Mackay Medicine Nursing and Management College, Taipei, Taiwan,5 National Taipei College of Nursing, Taipei, Taiwan6

Received 5 October 2004/ Returned for modification 3 December 2004/ Accepted 9 March 2005

Among 3,027 nontyphoidal Salmonella enterica isolates identified between January 1999 and December 2002 in a medical center in northern Taiwan, 31 were resistant to the extended-spectrum cephalosporin ceftriaxone (1.02% [31/3,027]), including 2 in 1999 (0.36% [2/549]), 13 in 2000 (1.49% [13/870]), 7 in 2001 (0.78% [7/893]), and 9 in 2002 (1.26% [9/715]). Sixteen of these isolates belonged to Salmonella serogroup B, nine belonged to serogroup C, four belonged to serogroup D, and two belonged to serogroup E. The majority were from stool cultures. The mechanism of resistance was investigated for eight isolates, including three S. enterica serovar Typhimurium, one S. enterica serovar Wagenia, one S. enterica serovar Senftenberg, one S. enterica serovar Derby, one S. enterica serovar Panama, and one S. enterica serovar Duesseldorf isolate. All eight patients from whom these isolates were recovered had community-acquired infections. All eight isolates were resistant to ampicillin, ceftriaxone, and cefotaxime but susceptible to imipenem and ciprofloxacin. Ceftriaxone resistance was due to the production of the CMY-2 AmpC ß-lactamase by seven isolates and the CTX-M-14 ß-lactamase by the remaining isolate. Both ß-lactamase genes were carried on conjugative plasmids. In a 2.5-kb region encompassing the blaCMY-2 gene, at nucleotide 49 upstream of the start codon of blaCMY-2, three of the seven blaCMY-2-positive isolates had an A nucleotide and four had a G nucleotide. In conclusion, the ceftriaxone resistance of nontyphoidal Salmonella isolates in our hospital was attributed to the CTX-M-14 and CMY-2 ß-lactamases.

* Corresponding author. Mailing address: Microbiology Section, Department of Medical Research, Mackay Memorial Hospital, 45 Min-Sheng Road, Danshui 251, Taipei, Taiwan. Phone: 886-2-28094661, ext. 2414. Fax: 886-2-28094679. E-mail: cchiang{at}ms1.mmh.org.tw.

Journal of Clinical Microbiology, July 2005, p. 3237-3243, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3237-3243.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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