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Journal of Clinical Microbiology, July 2005, p. 3508-3511, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3508-3511.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of Unique Bacterial Gene Segments from Streptococcus mutans with Potential Relevance to Dental Caries by Subtraction DNA Hybridization

Deepak Saxena,1* Yihong Li,2 and Page W. Caufield1

Division of Diagnostics, Infectious Disease, and Health Promotion,1 Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 100102

Received 10 February 2005/ Returned for modification 22 February 2005/ Accepted 24 March 2005

Using DNA subtractive hybridization, 49 unique gene segments were identified from a strain of Streptococcus mutans that was isolated from a patient with severe early childhood caries (S-ECC). Further hybridization with DNA from other S. mutans strains isolated from both caries-active and caries-free subjects yielded five unique sequences of DNA common to strains associated with S-ECC.

* Corresponding author. Mailing address: Division of Diagnostics, Infectious Disease, and Heath Promotion, New York University College of Dentistry, 345 E. 24th Street, New York, NY 10010. Phone: (212) 998-9203. Fax: (212) 995-3994. E-mail: ds100{at}nyu.edu.

Journal of Clinical Microbiology, July 2005, p. 3508-3511, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3508-3511.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Saxena, D., Caufield, P. W., Li, Y., Brown, S., Song, J., Norman, R. (2008). Genetic Classification of Severe Early Childhood Caries by Use of Subtracted DNA Fragments from Streptococcus mutans. J. Clin. Microbiol. 46: 2868-2873 [Abstract] [Full Text]  
  • Caufield, P. W., Saxena, D., Fitch, D., Li, Y. (2007). Population Structure of Plasmid-Containing Strains of Streptococcus mutans, a Member of the Human Indigenous Biota. J. Bacteriol. 189: 1238-1243 [Abstract] [Full Text]  
  • Waterhouse, J. C., Russell, R. R. B. (2006). Dispensable genes and foreign DNA in Streptococcus mutans. Microbiology 152: 1777-1788 [Abstract] [Full Text]  


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