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Journal of Clinical Microbiology, July 2005, p. 3551-3554, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3551-3554.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fatal Reactivation of Postnatal Cytomegalovirus Infection with Rapid Emergence of Ganciclovir Resistance in an Infant after Allogeneic Stem Cell Transplantation

Sebastian Voigt,1*,{dagger} Detlef Michel,2,{dagger} Olivia Kershaw,3 Jörn-Sven Kühl,1 Thomas Mertens,2 Wolfram Ebell,1 and Helga Meisel3*

Pediatric Bone Marrow Transplant Unit, Charité Campus Virchow Klinikum,1 Institute of Virology, Charité Campus Mitte, University Medicine Berlin, Berlin, Germany,3 Department of Virology, Institute for Microbiology and Immunology, University Hospital Ulm, Ulm, Germany2

Received 7 February 2005/ Returned for modification 1 April 2005/ Accepted 6 April 2005

Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.

* Corresponding author. Mailing address for Sebastian Voigt: Pediatric Bone Marrow Transplant Unit, Charité Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. Phone: 49 30 450 566237. Fax: 49 30 450 566937. E-mail: sebastian.voigt{at}charite.de. Mailing address for Helga Meisel: Institute of Virology, Charité Campus Mitte, Schumannstr. 20/21, 10117 Berlin, Germany. Phone: 49 30 450 525141. Fax: 49 30 450 525907. E-mail: helga.meisel{at}charite.de.

{dagger} S.V. and D.M. contributed equally to this work.

Journal of Clinical Microbiology, July 2005, p. 3551-3554, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3551-3554.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gohring, K., Feuchtinger, T., Mikeler, E., Lang, P., Jahn, G., Handgretinger, R., Hamprecht, K. (2009). Dynamics of the Emergence of a Human Cytomegalovirus UL97 Mutant Strain Conferring Ganciclovir Resistance in a Pediatric Stem-Cell Transplant Recipient. J. Mol. Diagn. 11: 364-368 [Abstract] [Full Text]  


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