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Journal of Clinical Microbiology, August 2005, p. 4172-4174, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4172-4174.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Prevalence of Herpes Simplex Virus (Types 1 and 2), Varicella-Zoster Virus, Cytomegalovirus, and Human Herpesvirus 6 and 7 DNA in Cerebrospinal Fluid of Middle Eastern Patients with Encephalitis

Ali I. Ibrahim,1 Michel T. Obeid,1 Muhidien J. Jouma,1 Klaus Roemer,2 Nikolaus Mueller-Lantzsch,2 and Barbara C. Gärtner2*

Department of Clinical Chemistry and Microbiology, University of Damascus, Syria,1 Department of Virology, University of Saarland Medical School, Homburg/Saar, Germany2

Received 31 March 2005/ Returned for modification 10 May 2005/ Accepted 14 May 2005

HSV-1 DNA was detected in 32 (30%) of 106 cerebrospinal fluid samples from patients with encephalitis. Cytomegalovirus, varicella-zoster virus, and human herpesvirus 6 (HHV-6) DNAs were each detected in three patients (3%); herpes simplex virus type 2 (HSV-2) and HHV-7 PCRs were negative. HSV detection was associated with seizure (P = 0.02), especially focal seizure (P = 0.0002), and pathological computed tomography (P = 0.02) with focal lesions (P = 0.0004).


* Corresponding author. Mailing address: University of Saarland Medical School, Department of Virology, Haus 47, D-66421 Homburg/Saar, Germany. Phone: 49 6841 1623950. Fax: 49 6841 1623980. E-mail: vibgae{at}uniklinik-saarland.de.


Journal of Clinical Microbiology, August 2005, p. 4172-4174, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4172-4174.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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  • Ward, K. N., Leong, H. N., Thiruchelvam, A. D., Atkinson, C. E., Clark, D. A. (2007). Human Herpesvirus 6 DNA Levels in Cerebrospinal Fluid Due to Primary Infection Differ from Those Due to Chromosomal Viral Integration and Have Implications for Diagnosis of Encephalitis. J. Clin. Microbiol. 45: 1298-1304 [Abstract] [Full Text]