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Journal of Clinical Microbiology, August 2005, p. 4183-4185, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4183-4185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Dissemination of CTX-M-Type Extended-Spectrum ß-Lactamase Genes to Unusual Hosts

Claudia Mugnaioli,1 Francesco Luzzaro,2 Filomena De Luca,1 Gioconda Brigante,2 Gianfranco Amicosante,3 and Gian Maria Rossolini1*

Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Università di Siena, I-53100 Siena,1 Laboratorio di Microbiologia Ospedale di Circolo, Università dell'Insubria, I-21100 Varese,2 Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100 L'Aquila, Italy3

Received 25 January 2005/ Returned for modification 14 February 2005/ Accepted 25 April 2005

A Citrobacter amalonaticus and a Morganella morganii producing the CTX-M-1 extended-spectrum ß-lactamase (ESBL) were isolated from an area where this enzyme is now widespread in Escherichia coli. This is the first report of CTX-M-1 in the former species. In both cases the ESBL determinant was possibly acquired by these unusual hosts in vivo, after coinfection with E. coli strains carrying conjugative plasmids encoding CTX-M-1.

* Corresponding author. Mailing address: Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Università di Siena, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy. Phone: 39-0577-233328. Fax: 39-0577-233334. E-mail: rossolini{at}unisi.it.

Journal of Clinical Microbiology, August 2005, p. 4183-4185, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4183-4185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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