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Journal of Clinical Microbiology, August 2005, p. 4215-4217, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4215-4217.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

High Seroprevalence of Herpes Simplex Virus Type 2 Infection in French Human Immunodeficiency Virus Type 1-Infected Outpatients

Laurent Andréoletti,1* Emmanuel Piednoir,1 Jérôme Legoff,2 Véronique Brodard,1 Isabelle Beguinot,1 Christophe Strady,1 Christine Rouger,1 Christophe Piketty,2 Ali Si-Mohamed,2 Michel Daniel Kazatchkine,2 Jean-Elie Malkin,3 and Laurent Bélec2

Unité de Virologie Médicale, Unité d'Hygiène Hospitalière et Service des Maladies Infectieuses, Hôpital Robert Debré, Centre Hospitalo-Universitaire de Reims, and IFR-53/EA-3798, Faculté de Médecine de Reims, Reims,1 Unité de Virologie Médicale et Service d'Immunologie Clinique, Hôpital Européen Georges Pompidou,2 Centre Médical de l'Institut Pasteur, Paris, France3

Received 22 February 2005/ Returned for modification 25 April 2005/ Accepted 19 May 2005

Using commercially available herpes simplex virus (HSV) type-specific serological diagnostic tests, HSV type 2 (HSV-2) antibody prevalence was assessed in two parallel prospective studies including 534 human immunodeficiency virus type 1 (HIV-1)-infected outpatients living in two areas of northern France. In the first cohort of 434 subjects, 223 (51%) individuals demonstrated a positive HSV-2 serological status while 66 (66%) of 100 subjects in the second cohort were seropositive for HSV-2 (51 versus 66%; P = 0.08). Among the 223 HSV-2-seropositive subjects identified in the first study cohort, only 22 (10%) had suffered from recurrent anogenital lesions during the past 12 months while 154 (69%) had no clinical history of herpesvirus infection. Our findings demonstrate high proportions of subclinical and undiagnosed HSV-2 infection in HIV-1-infected individuals and suggest that HSV type-specific serological testing in the French HIV-1-infected subpopulation could be an efficient strategy to diagnose clinically asymptomatic HSV-2 infections.

* Corresponding author. Mailing address: Laboratoire de Virologie, Service de Microbiologie, Hôpital Robert Debré, Avenue du Général Koenig, 51092 Reims Cedex, France. Phone: (33) 3 26 78 39 93. Fax: (33) 3 26 78 41 34. E-mail: landreoletti{at}chu-reims.fr.

Journal of Clinical Microbiology, August 2005, p. 4215-4217, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4215-4217.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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