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Journal of Clinical Microbiology, September 2005, p. 4377-4381, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4377-4381.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of Toxigenic Corynebacterium ulcerans Strains Isolated from Humans and Domestic Cats in the United Kingdom

Aruni De Zoysa,1* Peter M. Hawkey,2 Kathy Engler,3 Robert George,1 Gina Mann,1 William Reilly,4 David Taylor,5 and Androulla Efstratiou1

Health Protection Agency, Centre for Infections, Respiratory and Systemic Infection Laboratory, London NW9 5HT, United Kingdom,1 Health Protection Agency, Heartlands Hospital, Birmingham B9 5SS, United Kingdom, and Division of Immunity and Infection, Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom,2 Health Protection Agency, Regional Epidemiology Unit, Health Protection Agency, Leeds, United Kingdom,3 Scottish Centre for Infection and Environmental Health, Glasgow G3 7LN, United Kingdom,4 Department of Veterinary Bacteriology, University of Glasgow Veterinary School, Glasgow, United Kingdom5

Received 17 January 2005/ Returned for modification 12 March 2005/ Accepted 30 April 2005

In the United Kingdom there has been a marked increase in the number of human infections caused by toxigenic Corynebacterium ulcerans. During 2002 and 2003 the organism was also isolated from several domestic cats with bilateral nasal discharge. As C. ulcerans has never previously been isolated from cats, the 16S rRNA gene from three cat isolates was sequenced to confirm their species identities. Fifty clinical isolates from the United Kingdom isolated from 1986 to 2003 and seven cat isolates were characterized by ribotyping to determine whether the ribotypes of the cat isolates were genotypically related to those found for human clinical isolates. For comparison, the genotypes of 11 overseas isolates and 13 isolates from H. R. Carne's collection isolated between 1933 and 1979 were also determined. Strains isolated from domestic cats were found to exhibit the predominant ribotypes observed among human clinical isolates, suggesting that C. ulcerans isolated from cats could be a potential reservoir for human infection.

* Corresponding author. Mailing address: Health Protection Agency, Respiratory and Systemic Infection Laboratory, Specialist and Reference Microbiology Division, London NW9 5HT, United Kingdom. Phone: 44 (0) 20 8327 7160. Fax: 44 (0) 20 8205 6528. E-mail: aruni.dezoysa{at}hpa.org.uk.

Journal of Clinical Microbiology, September 2005, p. 4377-4381, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4377-4381.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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