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Journal of Clinical Microbiology, September 2005, p. 4567-4573, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4567-4573.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Human Coronavirus NL-63 Infections in Children: a 1-Year Study

Nathalie Bastien,1 Joan L. Robinson,2 Alena Tse,2 Bonita E. Lee,2 Laura Hart,1 and Yan Li1*

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba,1 Department of Pediatrics and Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada2

Received 17 May 2005/ Returned for modification 18 June 2005/ Accepted 25 June 2005

Human coronavirus NL63 (HCoV-NL63), a newly discovered coronavirus, has been associated with acute respiratory tract infections (ARI). Important questions pertaining to the contribution of HCoV-NL63 to ARI and its impact on public health remain. We reviewed HCoV-NL63 in specimens collected from 13 November 2002 to 31 December 2003 from the Stollery Children's Hospital on patients of <17 years of age to assess the role of this virus in ARI in children. Twenty-six of 1,240 specimens (2.1%) from seven outpatients and 19 inpatients aged 7 days to 9.5 years tested positive for HCoV-NL63 by reverse transcription-PCR. The majority of outpatients (86%) had upper respiratory tract infections, while the majority of inpatients (58%) had bronchiolitis. Peak HCoV-NL63 activity occurred in March. These results provide further evidence of the importance of HCoV-NL63 in ARI in children.

* Corresponding author. Mailing address: National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-6045. Fax: (204) 789-2082. E-mail: yan_li{at}phac-aspc.gc.ca.

Journal of Clinical Microbiology, September 2005, p. 4567-4573, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4567-4573.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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