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Journal of Clinical Microbiology, September 2005, p. 4649-4653, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4649-4653.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines

Mathew A. Diggle1 and Stuart C. Clarke1,2*

Scottish Meningococcus and Pneumococcus Reference Laboratory, Stobhill Hospital, Glasgow G21 3UW, United Kingdom,1 Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom2

Received 14 January 2005/ Returned for modification 7 March 2005/ Accepted 4 May 2005

During the 1990s, the incidence of meningococcal disease was high in the United Kingdom. This was due primarily to an increase in serogroup C disease, particularly that within the ET-37/ST-11 genetic lineage. Serogroup C meningococcal polysaccharide conjugate vaccines were introduced in the United Kingdom in 1999, but the sequence types of meningococci causing disease since that time have not yet been reported. We have used serogrouping and multilocus sequence typing to characterize meningococci from patients with invasive disease over a 4-year period and show that there is a significant increase in genetic diversity but no genetic evidence of capsule switching.

* Corresponding author. Present address: Dept. of Improving Health and Quality, Portsmouth City PCT, Finchdean House, Milton Road, Portsmouth PO3 6DP, United Kingdom. Phone: 44 23 9283 5020. Fax: 44 23 9723 3292. E-mail: stuartcclarke{at}hotmail.com.

Journal of Clinical Microbiology, September 2005, p. 4649-4653, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4649-4653.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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