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Journal of Clinical Microbiology, September 2005, p. 4834-4835, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4834-4835.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Syscan3, a Kit for Detection of Anti-Candida Antibodies for Diagnosis of Invasive Candidiasis

Annie Philip,1 Zekaver Odabasi,1 Gloria Matiuzzi,2 Victor L. Paetznick,1 Sze-Wee Tan,3 John Warmington,3,4 John H. Rex,1,{dagger} and Luis Ostrosky-Zeichner1*

Laboratory of Mycology Research, University of Texas—Houston Medical School, Houston, Texas,1 University of Texas M. D. Anderson Cancer Center, Houston, Texas,2 Rockeby Biomed, Ltd., Western Australia, Australia,3 School of Biomedical Sciences, Curtin University of Technology, Bentley, Western Australia, Australia4

Received 9 February 2005/ Returned for modification 6 May 2005/ Accepted 28 June 2005

Sera from 76 immunocompetent and 293 immunocompromised subjects were assayed for anti-Candida antibodies. The sensitivity, specificity, positive predictive value, and negative predictive value for invasive candidiasis were 74%, 75%, 62%, and 84% in the immunocompetent group and 15%, 60%, 1.7%, and 93% in the immunocompromised group, respectively. Syscan3 has high negative predictive value.

* Corresponding author. Mailing address: Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas—Houston Medical School, 6431 Fannin, MSB 2.112, Houston TX 77030. Phone: (713) 500-6733. Fax: (713) 500-5495. E-mail: Luis.Ostrosky-Zeichner{at}uth.tmc.edu.

{dagger} Present address: AstraZeneca Pharmaceuticals, Alderly Park, Macclesfield, United Kingdom.

Journal of Clinical Microbiology, September 2005, p. 4834-4835, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4834-4835.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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