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Journal of Clinical Microbiology, September 2005, p. 4844-4846, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4844-4846.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Low Concentrations of Nitric Oxide Exert a Hormetic Effect on Mycobacterium tuberculosis In Vitro

William Benjamin Brugmann and Marcia A. Firmani*

Louisiana State University Health Sciences Center, School of Allied Health Professions, Department of Clinical Laboratory Sciences, New Orleans, Louisiana 70112-2223

Received 21 March 2005/ Returned for modification 9 June 2005/ Accepted 13 June 2005

Susceptibilities of 12 clinical Mycobacterium tuberculosis isolates to acidified sodium nitrite (ASN) were compared. The results demonstrate that 8 of the 12 isolates exhibited enhanced survival levels in 1.5 mM ASN compared to levels in medium alone, suggesting that low concentrations of reactive nitrogen intermediates have a hormetic effect on M. tuberculosis in vitro.

* Corresponding author. Mailing address: Louisiana State University Health Sciences Center, School of Allied Health Professions, Department of Clinical Laboratory Sciences, 1900 Gravier Street, New Orleans, LA 70112-2223. Phone: (504) 568-4280. Fax: (504) 568-6761. E-mail: mfirma{at}lsuhsc.edu.

Journal of Clinical Microbiology, September 2005, p. 4844-4846, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4844-4846.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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