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Journal of Clinical Microbiology, October 2006, p. 3811-3813, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.01197-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Basis of Resistance Displayed by Highly Ciprofloxacin-Resistant Salmonella enterica Serovar Typhi in Bangladesh

Samir K. Saha,1,2* Gary L. Darmstadt,2 Abdullah H. Baqui,2,4 Derrick W. Crook,3 M. Nurul Islam,1,{dagger} Maksuda Islam,1 Maqsud Hossain,4 Shams El Arifeen,4 Mathuram Santosham,2 and Robert E. Black2

Department of Microbiology, Dhaka Shishu (Children) Hospital, Dhaka 1207, Bangladesh,1 Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland,2 Infectious Diseases and Clinical Microbiology, University of Oxford, Oxford, United Kingdom,3 Child Health Programme, ICDDR,B, Dhaka, Bangladesh4

Received 11 June 2006/ Accepted 22 June 2006

Highly ciprofloxacin-resistant (MIC, 512 µg/ml) strains of Salmonella enterica serovar Typhi were isolated from the blood of typhoid patients in Dhaka, Bangladesh. The strains were indistinguishable by their antibiograms, biotypes, and variable-number tandem repeat types and had matching point mutations at positions 83 and 87 of the gyrA gene. The isolation of these strains in an area of high endemicity indicates the need for continuous surveillance of antibiotic resistance of S. enterica serovar Typhi and for the rationalized use of ciprofloxacin.

* Corresponding author. Mailing address: Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu (Children) Hospital, Dhaka 1207, Bangladesh. Phone: 880 2 9138594. Fax: 880 2 8611634. E-mail: sksaha{at}bangla.net.

{dagger} Present address: Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Md.

Journal of Clinical Microbiology, October 2006, p. 3811-3813, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.01197-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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