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Journal of Clinical Microbiology, November 2006, p. 3915-3917, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01305-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pilot Study of a Commercialized Human Papillomavirus (HPV) Genotyping Assay: Comparison of HPV Risk Group to Cytology and Histology{triangledown}

Philip E. Castle,1* Mark Sadorra,2 Francisco Garcia,3 E. Blair Holladay,4 and Janet Kornegay2

Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, Maryland,1 Roche Molecular Systems, Alameda, California,2 University of Arizona Health Sciences Center, Tucson, Arizona,3 Medical University of South Carolina, Charleston, South Carolina4

Received 26 June 2006/ Returned for modification 8 August 2006/ Accepted 30 August 2006

We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noncarcinogenic types > negative specimens) with increasing severities of cytologic interpretations (PTrend < 0.0005) and histologic diagnoses (PTrend < 0.0005).

* Corresponding author. Mailing address: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 5123, EPS MSC 7234, Bethesda, MD 20892-7234. Phone: (301) 435-3976. Fax: (301) 402-0916. E-mail: castlep{at}mail.nih.gov.

{triangledown} Published ahead of print on 13 September 2006.

Journal of Clinical Microbiology, November 2006, p. 3915-3917, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01305-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Castle, P. E., Sadorra, M., Lau, T., Aldrich, C., Garcia, F. A. R., Kornegay, J. (2009). Evaluation of a Prototype Real-Time PCR Assay for Carcinogenic Human Papillomavirus (HPV) Detection and Simultaneous HPV Genotype 16 (HPV16) and HPV18 Genotyping. J. Clin. Microbiol. 47: 3344-3347 [Abstract] [Full Text]  
  • Stevens, M. P., Garland, S. M., Tabrizi, S. N. (2008). Validation of an Automated Detection Platform for Use with the Roche Linear Array Human Papillomavirus Genotyping Test. J. Clin. Microbiol. 46: 3813-3816 [Abstract] [Full Text]  
  • Castle, P. E., Porras, C., Quint, W. G., Rodriguez, A. C., Schiffman, M., Gravitt, P. E., Gonzalez, P., Katki, H. A., Silva, S., Freer, E., Van Doorn, L.-J., Jimenez, S., Herrero, R., Hildesheim, A., for the CVT Group, (2008). Comparison of Two PCR-Based Human Papillomavirus Genotyping Methods. J. Clin. Microbiol. 46: 3437-3445 [Abstract] [Full Text]  
  • Castle, P. E., Solomon, D., Wheeler, C. M., Gravitt, P. E., Wacholder, S., Schiffman, M. (2008). Human Papillomavirus Genotype Specificity of Hybrid Capture 2. J. Clin. Microbiol. 46: 2595-2604 [Abstract] [Full Text]  
  • Gravitt, P. E., Schiffman, M., Solomon, D., Wheeler, C. M., Castle, P. E. (2008). A Comparison of Linear Array and Hybrid Capture 2 for Detection of Carcinogenic Human Papillomavirus and Cervical Precancer in ASCUS-LSIL Triage Study. Cancer Epidemiol. Biomarkers Prev. 17: 1248-1254 [Abstract] [Full Text]  
  • Castle, P. E., Gravitt, P. E., Solomon, D., Wheeler, C. M., Schiffman, M. (2008). Comparison of Linear Array and Line Blot Assay for Detection of Human Papillomavirus and Diagnosis of Cervical Precancer and Cancer in the Atypical Squamous Cell of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study. J. Clin. Microbiol. 46: 109-117 [Abstract] [Full Text]  
  • Castle, P. E., Dockter, J., Giachetti, C., Garcia, F. A.R., McCormick, M. K., Mitchell, A. L., Holladay, E. B., Kolk, D. P. (2007). A Cross-sectional Study of a Prototype Carcinogenic Human Papillomavirus E6/E7 Messenger RNA Assay for Detection of Cervical Precancer and Cancer. Clin. Cancer Res. 13: 2599-2605 [Abstract] [Full Text]  


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