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Journal of Clinical Microbiology, November 2006, p. 4066-4071, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00574-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Lymphogranuloma Venereum Prevalence in Sweden among Men Who Have Sex with Men and Characterization of Chlamydia trachomatis ompA Genotypes{triangledown}

Markus Klint,1 Margareta Löfdahl,2 Carolina Ek,3 Åsa Airell,4 Torsten Berglund,2,5 and Björn Herrmann1*

Department of Clinical Microbiology, Uppsala University Hospital, Uppsala,1 Department of Epidemiology, Swedish Institute for Infectious Disease Control, Solna,2 Venhälsan Gay Clinic, Karolinska University Hospital, Stockholm,3 Department of Clinical Microbiology, Karolinska University Hospital Huddinge, Stockholm,4 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden5

Received 17 March 2006/ Returned for modification 22 June 2006/ Accepted 28 August 2006

An outbreak of lymphogranuloma venereum (LGV) infections has recently been reported from The Netherlands and other European countries. The Swedish surveillance system has identified three LGV cases since 2004, all with clinically suspected infection in men who have sex with men (MSM). In order to assess the prevalence of LGV in a high-risk group of MSM and include clinically atypical cases, retrospective analysis of 197 Chlamydia trachomatis-infected men was performed. Sequencing of the ompA gene showed a different serotype distribution compared to recent Swedish studies in heterosexual populations. The most common types were G (45%), D (27%), and J (26%), whereas the normally predominant type E accounted for only 4% of the chlamydia cases. Furthermore, certain ompA genotype variants of the dominant serotypes were highly prevalent among MSM, and the reason for this is discussed. No additional case of LGV was detected by retrospective analysis of the high-risk MSM population. This indicates that, thus far, LGV in Sweden is only a result of sporadic import from infected MSM clusters abroad.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Phone: (46) 18-611 39 52. Fax: (46) 18-55 91 57. E-mail: bjorn.herrmann{at}medsci.uu.se.

{triangledown} Published ahead of print on 13 September 2006.

Journal of Clinical Microbiology, November 2006, p. 4066-4071, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00574-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jalal, H., Stephen, H., Alexander, S., Carne, C., Sonnex, C. (2007). Development of Real-Time PCR Assays for Genotyping of Chlamydia trachomatis. J. Clin. Microbiol. 45: 2649-2653 [Abstract] [Full Text]  
  • Klint, M., Fuxelius, H.-H., Goldkuhl, R. R., Skarin, H., Rutemark, C., Andersson, S. G. E., Persson, K., Herrmann, B. (2007). High-Resolution Genotyping of Chlamydia trachomatis Strains by Multilocus Sequence Analysis. J. Clin. Microbiol. 45: 1410-1414 [Abstract] [Full Text]  


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