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Journal of Clinical Microbiology, November 2006, p. 4227-4228, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00722-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Susceptibilities of Propionibacterium acnes Ophthalmic Isolates to Ertapenem, Meropenem, and Cefepime{triangledown}

Robert Shames,1 Farhana Satti,1 Ernestine M. Vellozzi,2 and Miriam A. Smith1*

Division of Infectious Disease,1 Division of Microbiology, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 110422

Received 5 April 2006/ Returned for modification 26 June 2006/ Accepted 1 September 2006

We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 µg/ml to 0.75 µg/ml, 0.094 µg/ml to 1.5 µg/ml, and 1 µg/ml to 12 µg/ml for ertapenem, meropenem, and cefepime, respectively. Based on our excellent in vitro carbapenem susceptibility results, in vivo studies using ertapenem and meropenem in a rabbit model of P. acnes endophthalmitis are warranted.

* Corresponding author. Mailing address: Long Island Jewish Medical Center, Division of Infectious Disease, Staff House Rm. 226, Lakeville Rd., New Hyde Park, NY 11042. Phone: (718) 470-7290. Fax: (718) 470-0637. E-mail: msmith{at}lij.edu.

{triangledown} Published ahead of print on 13 September 2006.

Journal of Clinical Microbiology, November 2006, p. 4227-4228, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00722-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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