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Journal of Clinical Microbiology, November 2006, p. 4265-4269, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00649-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fatal Granulomatous Acanthamoeba Encephalitis Mimicking a Stroke, Diagnosed by Correlation of Results of Sequential Magnetic Resonance Imaging, Biopsy, In Vitro Culture, Immunofluorescence Analysis, and Molecular Analysis{triangledown}

Mehri S. McKellar,1* Lahar R. Mehta,2 John E. Greenlee,2 Devon C. Hale,1 Gregory C. Booton,3 Daryl J. Kelly,3 Paul A. Fuerst,3 Rama Sriram,4 and Govinda S. Visvesvara4

Division of Infectious Diseases, Department of Internal Medicine, University of Utah,1 Department of Neurology, University of Utah, Salt Lake City, Utah,2 Department of Evolution, Ecology, and Organismal Biology, Ohio State University, Columbus, Ohio,3 Division of Parasitology, Centers for Disease Control and Prevention, Atlanta, Georgia4

Received 26 March 2006/ Returned for modification 2 June 2006/ Accepted 7 September 2006

Amebic infections involving the central nervous system are rare and difficult to diagnose. Magnetic resonance imaging (MRI) at timed intervals may be helpful, where scans reveal enhancing lesions and increased signal. We report a unique case of granulomatous amebic encephalitis that was proven pathologically with progressive radiological findings on MRI.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of Utah, 30 North 1900 East, Room 4B19, Salt Lake City, UT 84132-2405. Phone: (801) 554-4200. Fax: (801) 585-3377. E-mail: mehri.mckellar{at}aidshealth.org.

{triangledown} Published ahead of print on 20 September 2006.

Journal of Clinical Microbiology, November 2006, p. 4265-4269, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00649-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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