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Journal of Clinical Microbiology, December 2006, p. 4436-4440, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01546-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility Patterns and Staphylococcal Cassette Chromosome mec Types of, as Well as Panton-Valentine Leukocidin Occurrence among, Methicillin-Resistant Staphylococcus aureus Isolates from Children and Adults in Middle Tennessee{triangledown}

Abdullah Kilic,1,3 Haijing Li,1 Charles W. Stratton,1,2 and Yi-Wei Tang1,2*

Departments of Medicine,1 Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232,2 Gulhane Military Medical Academy, Ankara 06018, Turkey3

Received 25 July 2006/ Returned for modification 29 September 2006/ Accepted 11 October 2006

Antimicrobial susceptibility patterns, Panton-Valentine leukocidin (PVL) occurrence, and staphylococcal cassette chromosome mec (SCCmec) types in methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from children and adults at Vanderbilt University Medical Center during a 12-month period were evaluated. A total of 1,315 MRSA isolates were collected, of which 748 (36.7%) were recovered from children. Among all isolates, 448 (34.1%) were SCCmec-II, and 847 (64.4%) were SCCmec-IV. More SCCmec-IV isolates were recovered from children than SCCmec-II isolates (424 [50.1%] versus 50 [11.2%]; odds ration [OR] = 7.98; P < 0.000001). The PVL gene was detected in 93.6% of SCCmec-IV isolates, in contrast to 0.2% in SCCmec-II isolates. Within SCCmec-IV isolates, a statistically higher PVL occurrence was noticed in children (98.1%) than in adults (89.1%) (OR = 6.34; P < 0.000001). Overall, SCCmec-II strains showed greater resistance than SCCmec-IV strains to clindamycin, erythromycin, levofloxacin, gentamicin, rifampin, minocycline, and trimethoprim-sulfamethoxazole. Both SCCmec-II and SCCmec-IV strains recovered from adults were more resistant to these antibiotics than those recovered from children. SCCmec-II strains were predominantly recovered from the respiratory tract, whereas SCCmec-IV strains were predominantly recovered from skin, soft tissue, abscesses, and surgical wounds. These data indicate that SCCmec-IV MRSA isolates frequently infect children in middle Tennessee and are likely to harbor the PVL gene.

* Corresponding author. Mailing address: Molecular Infectious Disease Laboratory, Vanderbilt University Hospital, 4605 TVC, Nashville, TN 37232-5310. Phone: (615) 322-2035. Fax: (615) 343-8420. E-mail: yiwei.tang{at}vanderbilt.edu.

{triangledown} Published ahead of print on 25 October 2006.

Journal of Clinical Microbiology, December 2006, p. 4436-4440, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01546-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yu, D., Chen, Y., Pan, Y., Li, H., McCormac, M. A., Tang, Y.-W. (2008). Staphylococcus gallinarum Bacteremia in a Patient with Chronic Hepatitis B Virus Infection. Annals of Clinical & Laboratory Science 38: 401-404 [Abstract] [Full Text]  
  • Tang, Y.-W., Kilic, A., Yang, Q., McAllister, S. K., Li, H., Miller, R. S., McCormac, M., Tracy, K. D., Stratton, C. W., Han, J., Limbago, B. (2007). StaphPlex System for Rapid and Simultaneous Identification of Antibiotic Resistance Determinants and Panton-Valentine Leukocidin Detection of Staphylococci from Positive Blood Cultures. J. Clin. Microbiol. 45: 1867-1873 [Abstract] [Full Text]  
  • Moroney, S. M., Heller, L. C., Arbuckle, J., Talavera, M., Widen, R. H. (2007). Staphylococcal Cassette Chromosome mec and Panton-Valentine Leukocidin Characterization of Methicillin-Resistant Staphylococcus aureus Clones. J. Clin. Microbiol. 45: 1019-1021 [Abstract] [Full Text]  


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