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Journal of Clinical Microbiology, December 2006, p. 4537-4540, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01537-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification of a Novel, Invasive, Not-Yet-Cultivated Treponema sp. in the Large Intestine of Pigs by PCR Amplification of the 16S rRNA Gene{triangledown}

Lars Mølbak,1*,{dagger} Kirstine Klitgaard,1,{dagger} Tim K. Jensen,1 Marja Fossi,2 and Mette Boye1

Danish Institute for Food and Veterinary Research, Bülowsvej 27, 1790 Copenhagen V, Denmark,1 Finnish Food Safety Authority Evira, Seinäjoki Research Unit, PB 198, 60101 Seinäjoki, Finland2

Received 25 July 2006/ Returned for modification 19 August 2006/ Accepted 16 September 2006

Laser capture microdissection in combination with fluorescent in situ hybridization was used to identify an unknown species of spirochetes from the pig colonic mucosa. The 16S rRNA gene was PCR amplified, and the closest related type strain was Treponema bryantiiT (90.1%). The spirochete, here named "Candidatus Treponema suis," was associated with colitis, including invasion of the surface epithelium as well as superficial parts of the mucosa.

* Corresponding author. Mailing address: Danish Institute for Food and Veterinary Research, Bülowsvej 27, DK-1790 Copenhagen V, Denmark. Phone: 45 72346361. Fax: 45 72346001. E-mail: lam{at}dfvf.dk.

{triangledown} Published ahead of print on 27 September 2006.

{dagger} Lars Mølbak and Kirstine Klitgaard contributed equally to this work.

Journal of Clinical Microbiology, December 2006, p. 4537-4540, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01537-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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