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Journal of Clinical Microbiology, December 2006, p. 4596-4597, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01531-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Presence of the exoU Gene of Pseudomonas aeruginosa Is Correlated with Cytotoxicity in MDCK Cells but Not with Colonization in BALB/c Mice{triangledown}

Hsi-Hsun Lin,1 Shiao-ping Huang,2 Hsiu-Chen Teng,3 Dar-Der Ji,4 Yao-Shen Chen,5 and Ya-Lei Chen6*

Department of Infectious Disease, E-DA Hospital/I-Shou University, Kaoshiung, Taiwan,1 Department of Medical Technology, Fooyin University, Kaoshiung, Taiwan,2 Department of Healthcare Management, Fooyin University, Kaoshiung, Taiwan,3 Division of Research and Diagnosis, Center for Disease Control, Taipei, Taiwan,4 Section of Infectious Disease, Kaoshiung Veterans General Hospital, Kaoshiung, Taiwan,5 Department of Biotechnology, National Kaoshiung Normal University, Kaoshiung, Taiwan6

Received 25 July 2006/ Returned for modification 13 September 2006/ Accepted 6 October 2006

A total of 141 independent strains of Pseudomonas aeruginosa with different heterogeneities in the exo gene (exoS, exoT, exoU, and exoY) background were examined for their pathogenic roles. Results indicated that the exoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.

* Corresponding author. Mailing address: Department of Biotechnology, National Kaoshiung Normal University, Kaoshiung, Taiwan. Fax: 886-7-615-1353. Phone: 886-7-605-1366. E-mail: dan1001{at}ma31.hinet.net.

{triangledown} Published ahead of print on 18 October 2006.

Journal of Clinical Microbiology, December 2006, p. 4596-4597, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01531-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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