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Journal of Clinical Microbiology, February 2006, p. 513-517, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.513-517.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparison of Physician- and Self-Collected Genital Specimens for Detection of Human Papillomavirus in Men

Brenda Y. Hernandez,1* K. McDuffie,1 M. T. Goodman,1 L. R. Wilkens,1 P. Thompson,1 X. Zhu,1 W. Wong,2 and L. Ning2

Cancer Research Center of Hawaii,1 University Health Services, University of Hawaii, Honolulu, Hawaii2

Received 13 October 2005/ Returned for modification 23 November 2005/ Accepted 29 November 2005

There is currently no consensus regarding the most appropriate methods of sampling for the detection of genital human papillomavirus (HPV) in men. We employed a recently developed collection method involving abrasion and moistened swabbing of the genital skin surface for the detection of HPV in a cohort of 136 university-affiliated males in Hawaii. Genital specimens collected by physicians using this method were compared with self-collected specimens from the same individuals obtained 24 h later. Self-collected specimens yielded a greater proportion of sufficient specimens than physician-collected specimens. HPV detection was comparable in physician- and self-collected specimens; detection was highest in the penile shaft (51.2% and 51.5%, respectively, P = 0.96), followed by the scrotum (41.2% and 46.2%, P = 0.43), the glans/coronal sulcus (31.9% and 33.1%, P = 0.84), and the foreskin (33.3% and 28.6%, P = 0.74). Site-specific agreement in HPV detection between paired physician- and self-collected samples ranged from 67.2% (kappa = 0.34) for the penile shaft to 95.0% (kappa = 0.89) for the foreskin. There was a high degree of concordance in HPV genotypes in HPV-positive pairs. The most common type was HPV type 84, which comprised approximately 15% of the specimens. The emery paper-swab method offers an efficient sampling method for genital HPV DNA detection in men that could be used both within and outside of the clinical setting.

* Corresponding author. Mailing address: Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813. Phone: (808) 586-2992. Fax: (808) 586-2982. E-mail: brenda{at}crch.hawaii.edu.

Journal of Clinical Microbiology, February 2006, p. 513-517, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.513-517.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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