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Journal of Clinical Microbiology, February 2006, p. 628-631, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.628-631.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Sonication of Explanted Prosthetic Components in Bags for Diagnosis of Prosthetic Joint Infection Is Associated with Risk of Contamination

Andrej Trampuz,1 Kerryl E. Piper,1 Arlen D. Hanssen,1,3 Douglas R. Osmon,1 Franklin R. Cockerill,2 James M. Steckelberg,1 and Robin Patel1,2*

Division of Infectious Diseases, Department of Internal Medicine,1 Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology,2 Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota3

Received 14 November 2005/ Accepted 16 November 2005

Explanted orthopedic implants from 54 patients with aseptic failure and 24 patients with prosthetic knee or hip infection were sonicated in polyethylene bags. The sensitivities of periprosthetic tissue and sonicate fluid cultures for the diagnosis of prosthetic joint infection were 54% and 75%, whereas the specificities were 98% and 87%, respectively. Sonication in bags improved bacterial recovery from the surface of orthopedic implants; however, it lacked specificity, due to bag leakage.

* Corresponding author. Mailing address: Division of Infectious Diseases, Mayo Clinic College of Medicine, 200 First St. S.W., Rochester, MN 55905. Phone: (507) 255-6482. Fax: (507) 284-9066. E-mail: patel.robin{at}mayo.edu.

Journal of Clinical Microbiology, February 2006, p. 628-631, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.628-631.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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