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Journal of Clinical Microbiology, February 2006, p. 640-642, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.640-642.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Detection of Six Copies of the Capsulation b Locus in a Haemophilus influenzae Type b Strain Isolated from a Splenectomized Patient with Fulminant Septic Shock

Marina Cerquetti,1* Rita Cardines,1 Maria Giufrè,1 Annalisa Castella,2 Monica Rebora,3 Paola Mastrantonio,1 and Marta Luisa Ciofi degli Atti4

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy,1 Department of Public Health and Microbiology, Università degli Studi di Torino, Turin, Italy,2 SS Annunziata Hospital, Savigliano, Italy,3 National Centre of Epidemiology Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy4

Received 18 November 2005/ Accepted 28 November 2005

We report on the first detection of six copies of the capsulation b locus in a Haemophilus influenzae type b strain isolated from a splenectomized patient with fulminant septic shock associated with disseminated intravascular coagulation and death. The unusual amplification of the locus might have contributed to the rare and severe clinical presentation.

* Corresponding author. Mailing address: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Phone: 3906 49902343. Fax: 3906 49387112. E-mail: mcerquet{at}iss.it.

Journal of Clinical Microbiology, February 2006, p. 640-642, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.640-642.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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