This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Skiest, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Skiest, D. J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, February 2006, p. 655-656, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.655-656.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Treatment Failure Resulting from Resistance of Staphylococcus aureus to Daptomycin

Daniel J. Skiest*

Division of Infectious Diseases, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9113

Received 28 September 2005/ Returned for modification 8 November 2005/ Accepted 9 November 2005

Daptomycin, a new cyclic lipopeptide, was recently approved for the treatment of infections by gram-positive organisms, including infections with methicillin-resistant Staphylococcus aureus (MRSA). A patient infected with infected with MRSA developed resistance to daptomycin after prolonged exposure, which resulted in clinical failure. Clinicians should be aware of the possibility of daptomycin resistance and should consider routine testing for daptomycin susceptibility.

* Mailing address: Baystate Medical Center, Division of Infectious Diseases, 759 Chestnut St., Springfield, MA 01199. Phone: (413) 794-5376. Fax: (413) 794-4199. E-mail: daniel.skiest{at}bhs.org.

Journal of Clinical Microbiology, February 2006, p. 655-656, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.655-656.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Miro, J. M., Garcia-de-la-Maria, C., Armero, Y., Soy, D., Moreno, A., del Rio, A., Almela, M., Sarasa, M., Mestres, C. A., Gatell, J. M., Jimenez de Anta, M. T., Marco, F., and the Hospital Clinic Experimental Endocarditis, (2009). Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53: 4172-4177 [Abstract] [Full Text]  
  • Murillo, O., Garrigos, C., Pachon, M. E., Euba, G., Verdaguer, R., Cabellos, C., Cabo, J., Gudiol, F., Ariza, J. (2009). Efficacy of High Doses of Daptomycin versus Alternative Therapies against Experimental Foreign-Body Infection by Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53: 4252-4257 [Abstract] [Full Text]  
  • Schoen, C., Unzicker, C., Stuhler, G., Elias, J., Einsele, H., Grigoleit, G. U., Abele-Horn, M., Mielke, S. (2009). Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient. J. Clin. Microbiol. 47: 2328-2331 [Abstract] [Full Text]  
  • Moise, P. A, Hershberger, E., Amodio-Groton, M. I, Lamp, K. C (2009). Safety and Clinical Outcomes when Utilizing High-Dose (>=8 mg/kg) Daptomycin Therapy. The Annals of Pharmacotherapy 43: 1211-1219 [Abstract] [Full Text]  
  • Yang, S.-J., Xiong, Y. Q., Dunman, P. M., Schrenzel, J., Francois, P., Peschel, A., Bayer, A. S. (2009). Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains. Antimicrob. Agents Chemother. 53: 2636-2637 [Abstract] [Full Text]  
  • Memmi, G., Filipe, S. R., Pinho, M. G., Fu, Z., Cheung, A. (2008). Staphylococcus aureus PBP4 Is Essential for {beta}-Lactam Resistance in Community-Acquired Methicillin-Resistant Strains. Antimicrob. Agents Chemother. 52: 3955-3966 [Abstract] [Full Text]  
  • Warren, R. E. (2008). Daptomycin in endocarditis and bacteraemia: a British perspective. J Antimicrob Chemother 62: iii25-iii33 [Abstract] [Full Text]  
  • Ge, Y., Biek, D., Talbot, G. H., Sahm, D. F. (2008). In Vitro Profiling of Ceftaroline against a Collection of Recent Bacterial Clinical Isolates from across the United States. Antimicrob. Agents Chemother. 52: 3398-3407 [Abstract] [Full Text]  
  • Murthy, M. H., Olson, M. E., Wickert, R. W., Fey, P. D., Jalali, Z. (2008). Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate. J Med Microbiol 57: 1036-1038 [Abstract] [Full Text]  
  • Huang, Y.-T., Hsiao, C.-H., Liao, C.-H., Lee, C.-W., Hsueh, P.-R. (2008). Bacteremia and Infective Endocarditis Caused by a Non-Daptomycin-Susceptible, Vancomycin-Intermediate, and Methicillin-Resistant Staphylococcus aureus Strain in Taiwan. J. Clin. Microbiol. 46: 1132-1136 [Abstract] [Full Text]  
  • Jones, T., Yeaman, M. R., Sakoulas, G., Yang, S.-J., Proctor, R. A., Sahl, H.-G., Schrenzel, J., Xiong, Y. Q., Bayer, A. S. (2008). Failures in Clinical Treatment of Staphylococcus aureus Infection with Daptomycin Are Associated with Alterations in Surface Charge, Membrane Phospholipid Asymmetry, and Drug Binding. Antimicrob. Agents Chemother. 52: 269-278 [Abstract] [Full Text]  
  • LaPlante, K. L., Mermel, L. A. (2007). In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model. Nephrol Dial Transplant 22: 2239-2246 [Abstract] [Full Text]  
  • Cheng, J., Thanassi, J. A., Thoma, C. L., Bradbury, B. J., Deshpande, M., Pucci, M. J. (2007). Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus. Antimicrob. Agents Chemother. 51: 2445-2453 [Abstract] [Full Text]  
  • Goldstein, F. (2007). The potential clinical impact of low-level antibiotic resistance in Staphylococcus aureus. J Antimicrob Chemother 59: 1-4 [Abstract] [Full Text]  
  • French, G. L. (2006). Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin. J Antimicrob Chemother 58: 1107-1117 [Abstract] [Full Text]  
  • Tyrrell, K. L., Citron, D. M., Warren, Y. A., Fernandez, H. T., Merriam, C. V., Goldstein, E. J. C. (2006). In Vitro Activities of Daptomycin, Vancomycin, and Penicillin against Clostridium difficile, C. perfringens, Finegoldia magna, and Propionibacterium acnes.. Antimicrob. Agents Chemother. 50: 2728-2731 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»