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Journal of Clinical Microbiology, April 2006, p. 1590-1591, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1590-1591.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fluoroquinolone Resistance in Ureaplasma parvum in the United States

Lynn Duffy,1 John Glass,2 Geraldine Hall,3 Robin Avery,3 Raymond Rackley,3 Scott Peterson,4 and Ken Waites1*

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama,1 J. Craig Venter Institute,2 The Institute for Genomic Research, Rockville, Maryland,4 Cleveland Clinic Foundation, Cleveland, Ohio3

Received 20 December 2005/ Returned for modification 26 January 2006/ Accepted 2 February 2006

We report the first case of naturally occurring fluoroquinolone resistance in Ureaplasma spp. from the United States. Resistance in this case probably developed as a result of mutations in the gyrA and parC genes of the DNA gyrase/topoisomerase IV complex that occurred in the presence of antimicrobial selective pressure.

* Corresponding author. Mailing address: Department of Pathology, WP 230, 619 19th St. South, University of Alabama at Birmingham, Birmingham, AL 35226. Phone: (205) 934-4960. Fax: (205) 975-4468. E-mail: waites{at}path.uab.edu.

Journal of Clinical Microbiology, April 2006, p. 1590-1591, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1590-1591.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lysnyansky, I., Mikula, I., Gerchman, I., Levisohn, S. (2009). Rapid Detection of a Point Mutation in the parC Gene Associated with Decreased Susceptibility to Fluoroquinolones in Mycoplasma bovis. Antimicrob. Agents Chemother. 53: 4911-4914 [Abstract] [Full Text]  
  • Beeton, M. L., Chalker, V. J., Kotecha, S., Spiller, O. B. (2009). Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinolone antibiotic resistance mutations from non-resistance polymorphism. J Antimicrob Chemother 64: 529-538 [Abstract] [Full Text]  
  • Waites, K. B., Crabb, D. M., Duffy, L. B. (2009). Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101. Antimicrob. Agents Chemother. 53: 2139-2141 [Abstract] [Full Text]  
  • Beeton, M. L., Chalker, V. J., Maxwell, N. C., Kotecha, S., Spiller, O. B. (2009). Concurrent Titration and Determination of Antibiotic Resistance in Ureaplasma Species with Identification of Novel Point Mutations in Genes Associated with Resistance. Antimicrob. Agents Chemother. 53: 2020-2027 [Abstract] [Full Text]  
  • Waites, K. B., Crabb, D. M., Duffy, L. B. (2008). Comparative In Vitro Activities of the Investigational Fluoroquinolone DC-159a and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas. Antimicrob. Agents Chemother. 52: 3776-3778 [Abstract] [Full Text]  


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