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Journal of Clinical Microbiology, May 2006, p. 1856-1858, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1856-1858.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Use of an Acute Seroconversion Panel To Evaluate a Third-Generation Enzyme-Linked Immunoassay for Detection of Human Immunodeficiency Virus-Specific Antibodies Relative to Multiple Other Assays

Brian Louie,* Mark W. Pandori, Ernest Wong, Jeffrey D. Klausner, and Sally Liska

San Francisco Department of Public Health, San Francisco, California

Received 9 November 2005/ Returned for modification 1 February 2006/ Accepted 24 February 2006

A human immunodeficiency virus type 1 (HIV-1)/HIV-2 antibody screening assay, the Genetic Systems HIV-1/HIV-2 PLUS O EIA, was compared to several established screening or confirmatory tests using an acute HIV seroconversion panel. The HIV-1/HIV-2 PLUS O EIA showed an improved sensitivity over all tested antibody screening methods, and detected antibody in 7 of 19 specimens found to be negative by a first-generation EIA but positive for the presence of HIV RNA.

* Corresponding author. Mailing address: San Francisco Department of Public Health, 101 Grove St., Rm. 412, San Francisco, CA 94102. Phone: (415) 554-2800. Fax: (415) 431-0651. E-mail: brian.louie{at}sfdph.org.

Journal of Clinical Microbiology, May 2006, p. 1856-1858, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1856-1858.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pandori, M. W., Hackett, J. Jr., Louie, B., Vallari, A., Dowling, T., Liska, S., Klausner, J. D. (2009). Assessment of the Ability of a Fourth-Generation Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and p24 Antigen To Detect both Acute and Recent HIV Infections in a High-Risk Setting. J. Clin. Microbiol. 47: 2639-2642 [Abstract] [Full Text]  
  • Ren, A., Louie, B., Rauch, L., Castro, L., Liska, S., Klausner, J. D., Pandori, M. W. (2008). Screening and confirmation of human immunodeficiency virus type 1 infection solely by detection of RNA. J Med Microbiol 57: 1228-1233 [Abstract] [Full Text]  
  • Louie, B., Wong, E., Klausner, J. D., Liska, S., Hecht, F., Dowling, T., Obeso, M., Phillips, S. S., Pandori, M. W. (2008). Assessment of Rapid Tests for Detection of Human Immunodeficiency Virus-Specific Antibodies in Recently Infected Individuals. J. Clin. Microbiol. 46: 1494-1497 [Abstract] [Full Text]  


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