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Journal of Clinical Microbiology, June 2006, p. 2250-2253, Vol. 44, No. 6
0095-1137/06/$08.00+0     doi:10.1128/JCM.00234-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immune Suppression as the Etiology of Failure To Detect Anti-HBc Antibodies in Patients with Chronic Hepatitis B Virus Infection

V. Avettand-Fenoel,1 D. Thabut,3 C. Katlama,2 T. Poynard,3 and V. Thibault1*

Virology Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France,1 Infectious Diseases Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France,2 Hepato-Gastro-Enterology Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France3

Received 2 February 2006/ Returned for modification 2 March 2006/ Accepted 7 April 2006

A lack of anti-HBc antibodies during chronic hepatitis B virus infection is a serological pattern that is rarely observed. In our series of 39 patients with such a confirmed profile, mutations within the precore/core gene were rarely found and the lack of antibody detection was mostly explained by concurrent immunosuppression and the low sensitivities of the serological assays.

* Corresponding author. Mailing address: Laboratoire de Virologie EA 2387, CERVI, Groupe Hospitalier Pitié-Salpêtrière (AP-HP), 91 Boulevard de l'Hôpital 75013 Paris, France. Phone: 33-1-42 17 74 26. Fax: 33-1-42 17 74 11. E-mail: vincent.thibault{at}psl.aphp.fr.

Journal of Clinical Microbiology, June 2006, p. 2250-2253, Vol. 44, No. 6
0095-1137/06/$08.00+0     doi:10.1128/JCM.00234-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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