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Journal of Clinical Microbiology, July 2006, p. 2587-2589, Vol. 44, No. 7
0095-1137/06/$08.00+0     doi:10.1128/JCM.00265-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Lamivudine Resistance of Hepatitis B Virus Masked by Coemergence of Mutations in Probe Region of the COBAS AMPLICOR Assay

Magnus Lindh,1,2* Charles Hannoun,1 Sebastian Malmström,1 Johan Lindberg,2 and Gunnar Norkrans2

Departments of Clinical Virology,1 Infectious Diseases, Göteborg University, Göteborg, Sweden2

Received 6 February 2006/ Returned for modification 20 March 2006/ Accepted 14 May 2006

The COBAS AMPLICOR hepatitis B virus assay targets a conserved region of the genome and is widely used to monitor treatment of hepatitis B in order to identify emerging resistance. However, the assay failed to recognize increasing viremia levels when YMDD mutations were paralleled by mutations in the segment targeted by the COBAS AMPLICOR probe.

* Corresponding author. Mailing address: Department of Clinical Virology, Göteborg University, Guldhedsgatan 10 B, 413 46 Göteborg, Sweden. Phone: 46 31 3424976. Fax: 46 31 827032. E-mail: magnus.lindh{at}microbio.gu.se.

Journal of Clinical Microbiology, July 2006, p. 2587-2589, Vol. 44, No. 7
0095-1137/06/$08.00+0     doi:10.1128/JCM.00265-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Thibault, V., Pichoud, C., Mullen, C., Rhoads, J., Smith, J. B., Bitbol, A., Thamm, S., Zoulim, F. (2007). Characterization of a New Sensitive PCR Assay for Quantification of Viral DNA Isolated from Patients with Hepatitis B Virus Infections. J. Clin. Microbiol. 45: 3948-3953 [Abstract] [Full Text]  


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