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Journal of Clinical Microbiology, August 2006, p. 2743-2749, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.00601-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Invasive Meningococcal Disease in Québec, Canada, Due to an Emerging Clone of ST-269 Serogroup B Meningococci with Serotype Antigen 17 and Serosubtype Antigen P1.19 (B:17:P1.19)

Dennis K. S. Law,1 Manon Lorange,2 Louise Ringuette,2 Réjean Dion,2 Michel Giguère,3 Averil M. Henderson,1 Jan Stoltz,1 Wendell D. Zollinger,4 Philippe De Wals,5 and Raymond S. W. Tsang1*

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada,1 Laboratoire de Santé Publique du Québec, Institut national de santé publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada,2 Agence de la santé et des services sociaux de Chaudière-Appalaches, Québec, Canada,3 Walter Reed Army Institute of Research, Washington, D.C.,4 Department of Social and Preventive Medicine, Laval University, and Institut National de Santé Publique du Québec, Québec City, Québec, Canada5

Received 21 March 2006/ Returned for modification 11 April 2006/ Accepted 31 May 2006

During periods of endemic meningococcal disease, serogroup B Neisseria meningitidis is responsible for a significant percentage of invasive diseases, and no particular clone or strain predominates (F. E. Ashton and D. A. Caugant, Can. J. Microbiol. 47: 293-289, 2001), However, in the winter of 2004 to 2005, a cluster of serogroup B meningococcal disease occurred in one region in the province of Québec, Canada. The N. meningitidis strain responsible for this cluster of cases was identified as sequence type ST-269 with the antigenic formula B:17:P1.19. Retrospective analysis of isolates from 2000 onwards showed that this clone first emerged in the province of Québec in 2003. The emergence of this clone of serogroup B meningococci occurred after a mass vaccination against serogroup C N. meningitidis, suggesting possible capsule replacement.

* Corresponding author. Mailing address: Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-6020. Fax: (204) 789-2018. E-mail: raymond_tsang{at}phac-aspc.gc.ca.

Journal of Clinical Microbiology, August 2006, p. 2743-2749, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.00601-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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