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Journal of Clinical Microbiology, August 2006, p. 3046-3047, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.00526-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Azole Resistance of Candida glabrata in a Case of Recurrent Fungemia

Brunella Posteraro,1 Mario Tumbarello,2 Marilena La Sorda,1 Teresa Spanu,1 Enrico Maria Trecarichi,2 Flavia De Bernardis,3 Giancarlo Scoppettuolo,2 Maurizio Sanguinetti,1* and Giovanni Fadda1

Departments of Microbiology,1 Infectious Diseases, Università Cattolica del Sacro Cuore,2 Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy3

Received 10 March 2006/ Returned for modification 12 April 2006/ Accepted 6 June 2006

We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.

* Corresponding author. Mailing address: Department of Microbiology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome 00168, Italy. Phone: 39 6 30154964. Fax: 39 6 3051152. E-mail: msanguinetti{at}rm.unicatt.it.

Journal of Clinical Microbiology, August 2006, p. 3046-3047, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.00526-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tumbarello, M., Sanguinetti, M., Trecarichi, E. M., La Sorda, M., Rossi, M., de Carolis, E., de Gaetano Donati, K., Fadda, G., Cauda, R., Posteraro, B. (2008). Fungaemia caused by Candida glabrata with reduced susceptibility to fluconazole due to altered gene expression: risk factors, antifungal treatment and outcome. J Antimicrob Chemother 62: 1379-1385 [Abstract] [Full Text]  


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