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Journal of Clinical Microbiology, September 2006, p. 3409-3412, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00515-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

rpoB Gene Mutations and Molecular Characterization of Rifampin-Resistant Mycobacterium tuberculosis Isolates from Shandong Province, China

Xin Ma,1,2* Haiying Wang,1 Yunfeng Deng,1 Zhimin Liu,1 Yong Xu,1 Xi Pan,2 James M. Musser,3 and Edward A. Graviss2

Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Tuberculosis Control Center, Jinan, Shandong, China,1 Department of Pathology, Baylor College of Medicine, Houston, Texas,2 Center for Human Molecular and Translational Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas3

Received 9 March 2006/ Returned for modification 8 May 2006/ Accepted 3 July 2006

Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.

* Corresponding author. Mailing address: Department of Pathology (206E), Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: (713) 798-8022. Fax: (713) 798-8895. E-mail: xma{at}bcm.edu.

Journal of Clinical Microbiology, September 2006, p. 3409-3412, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00515-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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