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Journal of Clinical Microbiology, January 2007, p. 231-233, Vol. 45, No. 1
0095-1137/07/$08.00+0     doi:10.1128/JCM.01243-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of Commercial Rubella Immunoglobulin G Avidity Assays{triangledown}

Samira Mubareka,1 Hannah Richards,2 Michael Gray,2 and Graham A. Tipples1,2*

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba,1 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada2

Received 16 June 2006/ Returned for modification 11 August 2006/ Accepted 25 October 2006

We compared the performances of five commercial rubella virus immunoglobulin G (IgG) avidity assays. The Adaltis (kappa = 0.28) and Diesse (kappa = 0.33) assays showed poor correlation, the Behring assay (kappa = 0.68) showed good correlation, and the Euroimmun (kappa = 0.95) and Radim (kappa = 0.94) assays showed excellent correlation with a well-established in-house rubella virus IgG avidity assay. The Euroimmun and Radim assays were statistically significantly better than the other commercial assays (P < 0.01).

* Corresponding author. Mailing address: National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada, R3E 3R2. Phone: (204) 789-6080. Fax: (204) 789-7039. E-mail: Graham_Tipples{at}phac-aspc.gc.ca.

{triangledown} Published ahead of print on 8 November 2006.

Journal of Clinical Microbiology, January 2007, p. 231-233, Vol. 45, No. 1
0095-1137/07/$08.00+0     doi:10.1128/JCM.01243-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vauloup-Fellous, C., Ursulet-Diser, J., Grangeot-Keros, L. (2007). Development of a Rapid and Convenient Method for Determination of Rubella Virus-Specific Immunoglobulin G Avidity. CVI 14: 1416-1419 [Abstract] [Full Text]  


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