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Journal of Clinical Microbiology, January 2007, p. 237-240, Vol. 45, No. 1
0095-1137/07/$08.00+0     doi:10.1128/JCM.01429-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Spoligotype Signatures in the Mycobacterium tuberculosis Complex{triangledown}

E. M. Streicher,1 T. C. Victor,1 G. van der Spuy,1 C. Sola,2 N. Rastogi,2 P. D. van Helden,1 and R. M. Warren1*

DST/NRF Centre of Excellence in Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa,1 Institut Pasteur de Guadeloupe, Pointe à Pitre, Guadeloupe2

Received 11 July 2006/ Returned for modification 27 August 2006/ Accepted 15 October 2006

Evolution of the direct repeat region in Mycobacterium tuberculosis has created unique spoligotype signatures specifically associated with IS6110-defined strain families. Spoligotyping signatures may enable the analysis of the strain population structure in different settings and will enable the rapid identification of strain families that acquire drug resistance or escape protective immunity in drug and vaccine trials.

* Corresponding author. Mailing address: DST/NRF Centre of Excellence in Biomedical TB Research, Department of Medical Biochemistry, Stellenbosch University, P.O. Box 19063, Tygerberg, South Africa 7505. Phone: 27-21-9389482. Fax: 27-21-9389476. E-mail: rw1{at}sun.ac.za.

{triangledown} Published ahead of print on 25 October 2006.

Journal of Clinical Microbiology, January 2007, p. 237-240, Vol. 45, No. 1
0095-1137/07/$08.00+0     doi:10.1128/JCM.01429-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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