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Journal of Clinical Microbiology, October 2007, p. 3393-3395, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.00828-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Large Sequence Polymorphisms Classify Mycobacterium tuberculosis Strains with Ancestral Spoligotyping Patterns{triangledown}

Laura Flores,1 Tran Van,2 Sujatha Narayanan,3 Kathryn DeRiemer,4 Midori Kato-Maeda,1 and Sebastien Gagneux2,5*

Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and the University of California, San Francisco, California,1 Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California,2 Tuberculosis Research Center, Chennai, India,3 School of Medicine, University of California, Davis, California,4 Institute for Systems Biology, Seattle, Washington5

Received 18 April 2007/ Returned for modification 24 June 2007/ Accepted 29 July 2007

Genomic deletion analysis revealed that strains of Mycobacterium tuberculosis exhibiting spoligotyping patterns with almost all spacers present belong either to a strain lineage that includes the W-Beijing strain family or to the ancestral strain lineage of M. tuberculosis.

* Corresponding author. Mailing address: Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103. Phone: (206) 732-1398. Fax: (206) 732-1299. E-mail: sgagneux{at}systemsbiology.org

{triangledown} Published ahead of print on 15 August 2007.

Journal of Clinical Microbiology, October 2007, p. 3393-3395, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.00828-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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