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Journal of Clinical Microbiology, October 2007, p. 3416-3418, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.01314-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Potential of a Simplified p24 Assay for Early Diagnosis of Infant Human Immunodeficiency Virus Type 1 Infection in Haiti{triangledown}

Erik George,1* Carole Anne Beauharnais,2 Emilio Brignoli,2 Francine Noel,2 Gyrlande Bois,2 Patricia De Matteis Rouzier,2 Martine Altenor,2 Daniel Lauture,2 Marlène Hosty,3 Sapna Mehta,4 Peter F. Wright,4 and Jean W. Pape2

Department of Medicine, Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York,1 Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti,2 Hopital Immaculeé Conception des Cayes, Les Cayes, Haiti,3 Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee4

Received 30 June 2007/ Accepted 19 July 2007

With global efforts to scale up the prevention of mother-to-child transmission services and pediatric antiretroviral therapy, there is an urgent need to introduce a simple, low-cost infant human immunodeficiency virus test in the field. We postulated that the p24 antigen capture enzyme-linked immunosorbent assay could be simplified by eliminating signal amplification without compromising diagnostic accuracy.

* Corresponding author. Present address: Hudson Infectious Disease Associates PC, 540 North State Road, Briarcliff Manor, NY 10510-1598. Phone: (914) 762-2276. Fax: (914) 762-2894. E-mail: erikgeorge{at}yepmail.net

{triangledown} Published ahead of print on 1 August 2007.

Journal of Clinical Microbiology, October 2007, p. 3416-3418, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.01314-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Finnegan, J., Nobel, K.-A., Lodha, R. (2009). Evidence behind the WHO Guidelines: Hospital Care for Children: What is the Role of HIV Antigen Testing in Infants <12-months Old?. J Trop Pediatr 55: 216-218 [Full Text]  
  • Cachafeiro, A., Sherman, G. G., Sohn, A. H., Beck-Sague, C., Fiscus, S. A. (2009). Diagnosis of Human Immunodeficiency Virus Type 1 Infection in Infants by Use of Dried Blood Spots and an Ultrasensitive p24 Antigen Assay. J. Clin. Microbiol. 47: 459-462 [Abstract] [Full Text]  


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