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Journal of Clinical Microbiology, November 2007, p. 3807-3810, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.01089-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of MChip with Historic Subtype H1N1 Influenza A Viruses, Including the 1918 "Spanish Flu" Strain{triangledown}

Chad L. Moore,1 James A. Smagala,1 Catherine B. Smith,2 Erica D. Dawson,3 Nancy J. Cox,2 Robert D. Kuchta,1 and Kathy L. Rowlen1,3*

Department of Chemistry and Biochemistry, UCB 215, University of Colorado at Boulder, Boulder, Colorado 80309,1 Influenza Division, The Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, Georgia 30333,2 InDevR, Inc., 2100 Central Ave., Suite 106, Boulder, Colorado 803013

Received 29 May 2007/ Returned for modification 10 August 2007/ Accepted 1 September 2007

The robustness of a recently developed diagnostic microarray for influenza, the MChip, was evaluated with 16 historic subtype H1N1 influenza A viruses (A/H1N1), including A/Brevig Mission/1/1918. The matrix gene segments from all 16 viruses were successfully detected on the array. An artificial neural network trained with temporally related A/H1N1 viruses identified A/Brevig Mission/1/1918 as influenza virus A/H1N1 with 94% probability.

* Corresponding author. Mailing address: Department of Chemistry and Biochemistry, UCB 215, University of Colorado at Boulder, Boulder, CO 80309. Phone: (303) 492-6533. Fax: (303) 492-5894. E-mail: Rowlen{at}colorado.edu

{triangledown} Published ahead of print on 12 September 2007.

Journal of Clinical Microbiology, November 2007, p. 3807-3810, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.01089-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gall, A., Hoffmann, B., Harder, T., Grund, C., Hoper, D., Beer, M. (2009). Design and Validation of a Microarray for Detection, Hemagglutinin Subtyping, and Pathotyping of Avian Influenza Viruses. J. Clin. Microbiol. 47: 327-334 [Abstract] [Full Text]  


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