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Journal of Clinical Microbiology, February 2007, p. 285-289, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.01335-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evidence for a Link between Parasite Genotype and Outcome of Infection with Entamoeba histolytica{triangledown} ,{dagger}

Ibne Karim M. Ali ,1,{ddagger} Utpal Mondal,2 Shantanu Roy,2,§ Rashidul Haque,2 William A. Petri Jr.,3 and C. Graham Clark1*

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, Great Britain,1 International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh,2 Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia3

Received 29 June 2006/ Returned for modification 21 August 2006/ Accepted 8 November 2006

The factors determining whether a person infected with Entamoeba histolytica develops disease remain obscure. To investigate whether the parasite genome contributes to the outcome, we have investigated the distribution of parasite genotypes among E. histolytica-infected individuals in Bangladesh. Samples were obtained from individuals who either were asymptomatic, had diarrhea/dysentery, or had developed a liver abscess. Genotypes were determined by using six tRNA-linked polymorphic markers, and their distributions among the three sample groups were evaluated. A significant population differentiation in the genotype distribution was found for four of the six individual markers as well as for the combined genotypes, suggesting that the parasite genome does contribute in some way to the outcome of infection with E. histolytica. The markers themselves do not indicate the nature of the underlying genetic differences, but they may be linked to loci that do have an impact on the outcome of infection.

* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, Great Britain. Phone: 44-207-927-2351. Fax: 44-207-636-8739. E-mail: graham.clark{at}lshtm.ac.uk.

{triangledown} Published ahead of print on 22 November 2006.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org.

{ddagger} Present address: Department of Microbiology, Stanford University School of Medicine, Stanford, CA 94305-5107.

§ Present address: Department of Medicine, University of Chicago, Chicago, IL 60637.

Journal of Clinical Microbiology, February 2007, p. 285-289, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.01335-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Santi-Rocca, J., Rigothier, M.-C., Guillen, N. (2009). Host-Microbe Interactions and Defense Mechanisms in the Development of Amoebic Liver Abscesses. Clin. Microbiol. Rev. 22: 65-75 [Abstract] [Full Text]  


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