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Journal of Clinical Microbiology, March 2007, p. 1032-1034, Vol. 45, No. 3
0095-1137/07/$08.00+0     doi:10.1128/JCM.01884-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

High Prevalence of Human Bocavirus Detected in Young Children with Severe Acute Lower Respiratory Tract Disease by Use of a Standard PCR Protocol and a Novel Real-Time PCR Protocol{triangledown}

Michael Kleines,1* Simone Scheithauer,1 Annette Rackowitz,3 Klaus Ritter,1 and Martin Häusler2

Division of Virology, Department of Medical Microbiology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany,1 Department of Pediatrics, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany,2 Department of Pediatric Cardiology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany3

Received 10 September 2006/ Returned for modification 14 November 2006/ Accepted 24 December 2006

The human bocavirus (HBoV) was recently isolated from respiratory tract samples. Within a study collective of children with severe lower respiratory tract disease, the patients testing positive for HBoV (12.8%) had a higher rate of underlying cardiopulmonary disease. Viral loads in respiratory tract specimens varied from 102 to 1010 genome equivalents/ml.

* Corresponding author. Mailing address: Division of Virology, Department of Medical Microbiology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany. Phone: 49 241 8088573. Fax: 49 241 8082483. E-mail: mkleines{at}ukaachen.de.

{triangledown} Published ahead of print on 10 January 2007.

Journal of Clinical Microbiology, March 2007, p. 1032-1034, Vol. 45, No. 3
0095-1137/07/$08.00+0     doi:10.1128/JCM.01884-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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