JCM
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
JCM.00042-07v1
45/4/1133    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meador, C. E.
Right arrow Articles by Vora, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meador, C. E.
Right arrow Articles by Vora, G. J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 2007, p. 1133-1139, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.00042-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Virulence Gene- and Pandemic Group-Specific Marker Profiling of Clinical Vibrio parahaemolyticus Isolates{triangledown}

Carolyn E. Meador,1 Michele M. Parsons,2 Cheryl A. Bopp,2 Peter Gerner-Smidt,2 John A. Painter,2 and Gary J. Vora3*

Nova Research, Inc., Alexandria, Virginia,1 National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,2 Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Washington, DC3

Received 5 January 2007/ Returned for modification 5 February 2007/ Accepted 8 February 2007

Vibrio parahaemolyticus is a halophilic bacterium capable of causing food- and waterborne gastroenteritis, wound infections, and septicemia in humans. The organism has recently received increasing attention, as the emergence of a new clone, V. parahaemolyticus O3:K6, has resulted in the first documented pandemic spread of V. parahaemolyticus. We used microarray analyses to explore the presence of known virulence factors and genetic markers thought to be specific for V. parahaemolyticus O3:K6 and its clonal derivatives. Analyses of 48 human clinical isolates collected between 1997 and 2005 revealed that the V. parahaemolyticus chromosome 2 type III secretion system is not specifically associated with pandemic strains and can be found in tdh-negative (i.e., Kanagawa-negative) clinical isolates. These results highlight the genetic dynamism of V. parahaemolyticus and aid in refining the genetic definition of the pandemic group members.

* Corresponding author. Mailing address: Naval Research Laboratory, Center for Bio/Molecular Science & Engineering, 4555 Overlook Avenue SW, Bldg. 30, Code 6910, Washington, DC 20375. Phone: (202) 767-0394. Fax: (202) 404-8688. E-mail: gvora{at}cbmse.nrl.navy.mil

{triangledown} Published ahead of print on 14 February 2007.

Journal of Clinical Microbiology, April 2007, p. 1133-1139, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.00042-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.