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Journal of Clinical Microbiology, April 2007, p. 1322-1324, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.02450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of Disk Diffusion and Etest Compared to Broth Microdilution for Antifungal Susceptibility Testing of Posaconazole against Clinical Isolates of Filamentous Fungi{triangledown}

Shawn A. Messer,1 Daniel J. Diekema,1,2* Richard J. Hollis,1 Linda B. Boyken,1 Shailesh Tendolkar,1 Jennifer Kroeger,1 and Michael A. Pfaller1,3

Departments of Pathology,1 Internal Medicine,2 Epidemiology, Roy J. and Lucille A. Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, Iowa 522423

Received 6 December 2006/ Returned for modification 8 January 2007/ Accepted 22 January 2007

We performed Etest, disk diffusion, and broth microdilution susceptibility testing of posaconazole against 146 clinical isolates of filamentous fungi. By using provisional breakpoints for comparison purposes only, categorical agreement between the results of the agar-based methods and those of broth microdilution were 96 to 98%, with no very major errors. These agar-based methods hold promise as simple and reliable methods for determining the posaconazole susceptibilities of filamentous fungi.

* Corresponding author. Mailing address: University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242. Phone: (319) 356-8615. Fax: (319) 356-4916. E-mail: daniel-diekema{at}uiowa.edu

{triangledown} Published ahead of print on 31 January 2007.

Journal of Clinical Microbiology, April 2007, p. 1322-1324, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.02450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Morris, M. I. (2009). Posaconazole: A new oral antifungal agent with an expanded spectrum of activity. Am J Health Syst Pharm 66: 225-236 [Abstract] [Full Text]  


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