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Journal of Clinical Microbiology, May 2007, p. 1607-1610, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.00306-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Toxin Profiles and Resistances to Macrolides and Newer Fluoroquinolones as Epidemicity Determinants of Clinical Isolates of Clostridium difficile from Warsaw, Poland{triangledown}

Hanna Pituch,1* Willem van Leeuwen,2 Kees Maquelin,3 Dorota Wultanska,1 Piotr Obuch-Woszczatynski,1 Grazyna Nurzynska,4 Haru Kato,5 Martin Reijans,6 Felicja Meisel-Mikolajczyk,1 Miroslaw Luczak,1,4 and Alex van Belkum2

Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland,1 Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands,2 Center for Optical Diagnostics and Therapy, Department of General Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands,3 Central Public Hospital of Medical University of Warsaw, Warsaw, Poland,4 Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan,5 Pathofinder BV, Oxfordlaan 70, Maastrich, The Netherlands6

Received 8 February 2007/ Accepted 14 February 2007

Amplified fragment length polymorphism genotypes, antibiotic resistance profiles, and toxin profiles of Clostridium difficile strains from Warsaw were determined. The isolates segregate in six major genotypes, coinciding with toxin profiles. Most of the toxin A-negative toxin B-positive toxin CDT-negative strains possess ermB, and several strains were resistant to fluoroquinolones. Resistograms and toxin types of C. difficile strains are epidemicity determinants.

* Corresponding author. Mailing address: Department of Medical Microbiology, Medical University of Warsaw, Chalubinski Street, 02-004 Warsaw, Poland. Phone: 48-22-628-2739. Fax: 48-22-628-2739. E-mail: hanna.pituch{at}ib.amwaw.edu.pl

{triangledown} Published ahead of print on 21 February 2007.

Journal of Clinical Microbiology, May 2007, p. 1607-1610, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.00306-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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