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Journal of Clinical Microbiology, May 2007, p. 1648-1651, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.00014-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Posaconazole Treatment for Apophysomyces elegans Rhino-Orbital Zygomycosis following Trauma for a Male with Well-Controlled Diabetes{triangledown}

T. D. Ferguson,1 S. D. Schniederjan,2 J. Dionne-Odom,1 M. E. Brandt,3 M. G. Rinaldi,4 F. S. Nolte,2 A. Langston,5 and S. M. Zimmer1*

Department of Medicine,1 Department of Pathology and Laboratory Medicine,2 Emory University School of Medicine, Atlanta, Georgia; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia,3 Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas,4 Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia5

Received 3 January 2007/ Returned for modification 15 February 2007/ Accepted 26 February 2007

We report a case of rhino-orbital zygomycosis in a 43-year-old male with well-controlled diabetes mellitus. The patient initially received liposomal amphotericin B, but the infection continued to progress, so posaconazole treatment was begun and eventually led to the cure of his infection. The causative agent was identified as Apophysomyces elegans, an emerging cause of zygomycosis in immunocompetent hosts.

* Corresponding author. Mailing address: Atlanta VAMC, Research 5A161, 1670 Clairmont Rd., Atlanta, GA 30033. Phone: (404) 321-6111, ext. 7570. Fax: (404) 329-2210. E-mail: szimmer{at}emory.edu

{triangledown} Published ahead of print on 7 March 2007.

Journal of Clinical Microbiology, May 2007, p. 1648-1651, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.00014-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Khan, Z. U., Ahmad, S., Brazda, A., Chandy, R. (2009). Mucor circinelloides as a Cause of Invasive Maxillofacial Zygomycosis: an Emerging Dimorphic Pathogen with Reduced Susceptibility to Posaconazole. J. Clin. Microbiol. 47: 1244-1248 [Abstract] [Full Text]  


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