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Journal of Clinical Microbiology, June 2007, p. 1673-1678, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02499-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Acute Postoperative Endophthalmitis Caused by Staphylococcus lugdunensis{triangledown}

C. Chiquet,1* A. Pechinot,2 C. Creuzot-Garcher,3 Y. Benito,4 J. Croize,5 S. Boisset,4 J. P. Romanet,1 G. Lina,6 F. Vandenesch,4 for the French Institutional Endophthalmitis Study Group

Department of Ophthalmology, CHU de Grenoble, Faculté de Médecine, Université Joseph Fourier, Grenoble, France,1 Department of Microbiology, CHU de Dijon, Dijon University, Dijon, France,2 Department of Ophthalmology, CHU de Dijon, Dijon University, Dijon, France,3 Université Lyon 1, Faculté de Médecine Laennec, Lyon F-69003, France, and Hospices Civils de Lyon, Laboratoire de Bactériologie, Hôpital Louis Pradel, Bron F-69677, France,4 Department of Microbiology, CHU de Grenoble, Faculté de Médecine, Université Joseph Fourier, Grenoble, France,5 Université de Lyon, Lyon F-69003, Université Lyon 1, Faculté de Médecine Laennec, Lyon F-69003, and Hospices Civils de Lyon, Laboratoire de Bactériologie, Hôpital Edouard Herriot, Lyon F-69003, France6

Received 13 December 2006/ Returned for modification 27 January 2007/ Accepted 17 March 2007

Acute postoperative endophthalmitis caused by Staphylococcus lugdunensis is infrequently reported in clinical studies. Five cases of acute postcataract surgery endophthalmitis caused by S. lugdunensis were taken from a multicenter prospective study conducted in four university-affiliated hospitals in France (2004 to 2005). These cases were characterized by severe ocular inflammation occurring with a mean delay of 7.6 days after cataract surgery, severe visual loss (hand motions or less in three cases), and dense infiltration of the vitreous. Each of these patients was initially treated by using a standard protocol with intravitreal (vancomycin and ceftazidime), systemic, and topical antibiotics. Given the severity of the endophthalmitis, even though bacteria were sensitive to intravitreal antibiotics, pars plana vitrectomy was needed in four cases. The final visual prognosis was complicated by severe retinal detachment in three cases. The microbiological diagnosis was reached by using conventional cultures with specific biochemical tests and eubacterial PCR amplification followed by direct sequencing.

* Corresponding author. Mailing address: Department of Ophthalmology, CHU de Grenoble, 38043 Grenoble Cedex 09, France. Phone: 33 476 765548. Fax: 33 476 767570. E-mail: cchiquet{at}chu-grenoble.fr

{triangledown} Published ahead of print on 28 March 2007.

Journal of Clinical Microbiology, June 2007, p. 1673-1678, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02499-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chiquet, C., Cornut, P.-L., Benito, Y., Thuret, G., Maurin, M., Lafontaine, P.-O., Pechinot, A., Palombi, K., Lina, G., Bron, A., Denis, P., Carricajo, A., Creuzot, C., Romanet, J.-P., Vandenesch, F., for the French Institutional Endophthalmitis Study, (2008). Eubacterial PCR for Bacterial Detection and Identification in 100 Acute Postcataract Surgery Endophthalmitis. IOVS 49: 1971-1978 [Abstract] [Full Text]  
  • Frank, K. L., del Pozo, J. L., Patel, R. (2008). From Clinical Microbiology to Infection Pathogenesis: How Daring To Be Different Works for Staphylococcus lugdunensis. Clin. Microbiol. Rev. 21: 111-133 [Abstract] [Full Text]  


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