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Journal of Clinical Microbiology, June 2007, p. 2011-2013, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.00232-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of Three Molecular Assays for Rapid Identification of Methicillin-Resistant Staphylococcus aureus{triangledown}

Patrice Francois,1* Manuela Bento,1 Gesuele Renzi,2 Stephan Harbarth,3 Didier Pittet,3 and Jacques Schrenzel1,2

Department of Internal Medicine, Service of Infectious Diseases/Genomic Research Laboratory,1 Clinical Microbiology Laboratory,2 Infection Control Program, University of Geneva Hospitals, Rue Micheli-du-Crest 24, CH-1211 Geneva 14, Switzerland3

Received 30 January 2007/ Returned for modification 21 March 2007/ Accepted 4 April 2007

One home-developed assay and two commercial assays for the rapid identification of methicillin-resistant Staphylococcus aureus (MRSA) were compared by use of a collection of clinical isolates displaying highly diverse genetic backgrounds. Our results suggest that users of orfX-staphylococcal cassette chromosome mec-based assays should repeatedly monitor the local epidemiology to minimize the risks of detection bias and the omission of emerging MRSA clones.

* Corresponding author. Mailing address: Service of Infectious Diseases/Genomic Research Laboratory, University of Geneva Hospitals, CH-1211 Geneva 14, Switzerland. Phone: 4122 372 9338. Fax: 4122 372 9830. E-mail: patrice.francois{at}genomic.ch

{triangledown} Published ahead of print on 11 April 2007.

Journal of Clinical Microbiology, June 2007, p. 2011-2013, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.00232-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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