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Journal of Clinical Microbiology, June 2007, p. 2020-2024, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02591-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Subtyping Method for Escherichia coli Shiga Toxin (Verocytotoxin) 2 Variants and Correlations to Clinical Manifestations{triangledown}

Søren Persson,1* Katharina E. P. Olsen,1 Steen Ethelberg,1 and Flemming Scheutz1,2

Department of Bacteriology, Mycology and Parasitology, Unit of Gastrointestinal Infections, Statens Serum Institut, Copenhagen, Denmark,1 The International Escherichia and Klebsiella Centre (WHO), Unit of Gastrointestinal Infections, Statens Serum Institut, Copenhagen, Denmark2

Received 27 December 2006/ Returned for modification 27 January 2007/ Accepted 4 April 2007

Shiga toxin 2 (Stx2) from Shiga toxin-producing Escherichia coli (STEC) was subtyped by a method involving partial sequencing of the stxAB2 operon. Of 255 strains from the Danish STEC cohort, all 20 cases of hemolytic-uremic syndrome were associated with subtype Stx2 (11 cases), subtype Stx2c (1 case), or the two combined (8 cases).

* Corresponding author. Mailing address: Department of Bacteriology, Mycology and Parasitology, The National Reference Laboratory for Enteropathogenic Bacteria, Unit of Gastrointestinal Infections, Statens Serum Institut, Artillerivej 5, Building 37B, 2300 Copenhagen S, Denmark. Phone: 45 3268 3648. Fax: 45 3268 8130. E-mail: SPN{at}ssi.dk

{triangledown} Published ahead of print on 19 April 2007.

Journal of Clinical Microbiology, June 2007, p. 2020-2024, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02591-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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