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Journal of Clinical Microbiology, July 2007, p. 2289-2292, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.00349-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

RTX Toxin Actin Cross-Linking Activity in Clinical and Environmental Isolates of Vibrio cholerae{triangledown}

Christina L. Cordero,1,{dagger} Shanmuga Sozhamannan,2 and Karla J. Fullner Satchell1*

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611,1 Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, Maryland 208522

Received 13 February 2007/ Returned for modification 24 April 2007/ Accepted 12 May 2007

Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.

* Corresponding author. Mailing address: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Tarry 3-713, Chicago, IL 60611. Phone: (312) 503-2162. Fax: (312) 503-1339. E-mail: k-satchell{at}northwestern.edu

{triangledown} Published ahead of print on 23 May 2007.

{dagger} Present address: The Joint Commission, Oakbrook Terrace, IL 60181.

Journal of Clinical Microbiology, July 2007, p. 2289-2292, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.00349-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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