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Journal of Clinical Microbiology, August 2007, p. 2720-2722, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00162-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Host Genetic Resistance to Symptomatic Norovirus (GGII.4) Infections in Denmark{triangledown}

Elin Kindberg,1,2 Britt Åkerlind,3 Christina Johnsen,4 Jenny Dahl Knudsen,5 Ole Heltberg,6 Göran Larson,7 Blenda Böttiger,4 and Lennart Svensson1*

Division of Molecular Virology, Medical Faculty, University of Linköping, Linköping, Sweden,1 Department of Forensic Genetics, National Board of Forensic Medicine, Linköping, Sweden,2 Division of Clinical Microbiology, University Hospital, Linköping, Sweden,3 Department of Virology, Statens Serum Institut, Copenhagen, Denmark,4 Department of Microbiology, Hvidovre Hospital, Hvidovre, Denmark,5 Department of Microbiology, Næstved Hospital, Næstved, Denmark,6 Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg, Sweden7

Received 22 January 2007/ Returned for modification 24 April 2007/ Accepted 21 May 2007

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

* Corresponding author. Mailing address: Division of Molecular Virology, Medical Faculty (IMK), University of Linköping, 581 85 Linköping, Sweden. Phone: 46 13 228803. Fax: 46 13 221375. E-mail: lensv{at}imk.liu.se

{triangledown} Published ahead of print on 30 May 2007.

Journal of Clinical Microbiology, August 2007, p. 2720-2722, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00162-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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